In the 2007 playoffs, the Red Sox swept the Los Angeles Angels of Anaheim in the ALDS. Facing the Cleveland Indians in the ALCS, Josh Beckett won Game 1 but the Sox stumbled, losing the next three games. Facing a 3-1 deficit and a must-win situation, Beckett pitched eight innings while surrendering only one run and striking out 11 in a masterful Game 5 win. The Sox captured their twelfth American League pennant by outscoring the Indians 30-5 over the final three games, winning the final two games at Fenway Park.

In the 2007 World Series, the Red Sox faced the Colorado Rockies. Beckett once again set the tone, pitching seven strong innings as the offense provided more than enough in a 13-1 victory. In Game 2, Schilling, Okajima, and Papelbon held the Rockies to one run again in a 2-1 game. Moving to Colorado, the Sox offense made the difference again in a 10-5 win. Finally, in Game 4, Jon Lester took Tim Wakefield's spot in the rotation and gave the Sox an impressive start, pitching 5 2/3 shutout innings. The Rockies threatened, but thanks to World Series MVP Mike Lowell and aided by a pinch-hit home run by outfielder Bobby Kielty, Papelbon registered another save as the Red Sox swept the Rockies in four games. The Red Sox captured their second title in four years.